We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hepatoprotective Effect of Nigella Sativa Seed Extract against Isoniazid and Rifampacin Induced Hepatotoxicity.
- Authors
Shreelakshmidevi S.; Jaikumar S.; Abilash Sc; Pammy S.
- Abstract
Background: Current century with advanced medical care still holds Tuberculosis as a prevalent condition around the world. The context to default is the adverse effects faced by patients taking anti-tubercular drugs. The most perilous among the adverse effect is hepatotoxicity and can be ameliorated by the effect of Nigella Sativa seeds. Objectives: To study the hepatoprotective role of Nigella Sativa seed extract against Isoniazid and Rifampicin induced hepatotoxicity. Materials & Method: The animals were divided into three groups with six animals in each group. Group I served as normal control, Group II served as positive control and received Isoniazid and Rifampicin for 10 days. Group III received Isoniazid and Rifampicin with Nigella Sativa seed extract 900mg/kg was given for 10 days. Blood samples where sent for AST, ALP, ALT analysis and the liver tissue for histopathology studies. Results: Table 2 showed decrease in AST, APL, and ALT values in group III when compared with group II. Histopathology showed reduced hepatotoxic changes in group III when compared with group II. Conclusion: The hepatoprotective property of Nigella Sativa seed extract will be a new path for safer and effective Tubercular therapy in developed and developing countries.
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 5, p344
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2019.01084.2