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- Title
The Significance of p53, Bcl-2, and HER-2/neu Protein Expression in Iraqi Females Breast Cancer Cell Line (AMJ13).
- Authors
Alawsi, Doha F.; Alshammari, Ahmed Majeed; Majeed, Maha F.
- Abstract
Breast cancer is a significant cause of death affecting females globally. It is the first cause of death from cancer in females in Iraq. AMJ13 Cell line derived from Iraqi female patient was established and used for drug development as in vitro model in cancer research. There are two apoptotic pathways—the extrinsic pathway (activated by ligand engagement of cell surface death receptors) and the intrinsic (mitochondrial) pathway: The biochemical assay for the Her2neu, P53, and Bcl-2 receptors have shown the clinical value of knowing the concentration of the receptor within the tissue. The immunocytochemical assay is rapidly taking over from the biochemical assay. This approach should apply to many more biomarkers detected by immunohistochemistry.
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 6, p1055
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2019.01425.6