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- Title
Physiological and Behavioral Changes of Male Rats Following Social Isolation Stress During Early-Adolescence and Fluoxetine Exposure.
- Authors
Habuk, Halla Abdul-Hadi C.; Al-Saadi, Haider Kamil Zaidan; Al-Harbi, Hussein Jasim
- Abstract
Stress experiences during youth lead to abnormal behavior profile in adulthood, including an increase in aggression, depression and anxiety disorders in humans. The animals during early- adolescent period (PD 35) were divided into the following groups: Group 1- Control. Group II- social isolation stress for 42 days -Negative control. Group III -The animals were treated with 10 mg/kg of the fluoxetine for 21 days in combination with isolation stress for 21 days, all groups followed by behavioral studies, and assessed the biochemical effects of exposure to stress and stress with drug. The results showed there was significantly improvement in the open field test including significantly increased locomotor and exploratory activity with decreased anxiety and aggressive behavior after treatment with fluoxetine compared to stress group. The results were also noted significant increase in the levels of brain serotonin in stress with fluoxetine group compared to stress group, The results showed significantly decreased in levels of dopamine and monoamine oxidase A in brain tissue of rats treated with fluoxetine compared to stress group. While corticosterone, testosterone and LH levels in stress rats showed significantly increased compared to stress with fluoxetine group.
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 10, p3037
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2019.03341.2