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- Title
Association of Severity of Autism Spectrum Disorder with Cardiac Autonomic Indices in Children.
- Authors
Bharath, Remya; Moodithaya, Shailaja S.; Kishan, Ashwini; U, Shrinivasa Bhat; N, Suchetha Kumari; Krishna Bhat, C. H.
- Abstract
Background & Objectives: Autism Spectrum Disorder (ASD) being a complex neuro-developmental disorder is found to be associated with Autonomic Nervous System (ANS) dysfunction. The sympathovagal continual dynamic excitatory- inhibitory interactions leads to Heart Rate Variability (HRV) which is an index of cardiac autonomic regulation. Aim of the study was to evaluate cardiac autonomic regulation in children with ASD at rest using short-term HRV analysis and to correlate it with severity of autism. Methods: A total of 30 subjects were evaluated in the study comprising of 15 ASD children and 15 healthy controls. A five minutes recording of resting ECG was carried out from which R-R intervals were procured and HRV indices were analysed. Frequency domain analysis of HRV was carried out and the following parameters were evaluated: Spectral powers in low frequency (LF) bands, High frequency (HF) bands, total power (TP), LF/HF ratio and average heart rate (HR) were evaluated. HRV indices between the groups were compared using Student’s t test. Severity of autism was correlated with the evaluated HRV indices using Pearson correlation test. Results: Cardiac sympathetic activity as assessed by low frequency power spectrum (‘p’ value 0.034) and total power (‘p’ value 0.023) of the HRV spectrum was significantly higher in autistic children compared to that of normal controls. However, the association between severity of ASDs and HRV indices were not statistically significant. Conclusion: Study concludes that here was no significant association between HRV indices and severity of autism.
- Publication
Indian Journal of Public Health Research & Development, 2020, Vol 11, Issue 6, p964
- ISSN
0976-0245
- Publication type
Academic Journal