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- Title
Anti-stress and Nootropic activity of aqueous extract of Artocarpus heterophyllus fruit, and y-maze test in rodents.
- Authors
Pateria, Radha; Joshi, Ankur; Pathan, Javed; Dwevedi, Sangeeta; Malviya, Sapna; Kharia, Anil
- Abstract
Artocarpus heterophyllus also known as jack fruit or kathal, belongs to family Moraceae. Fruits of this plant have been used traditionally to treat a variety of diseases. The current study was done to evaluate anti-stress activity in rats subjected to forced swim stress one hour after daily treatment of Artocarpus heterophyllus extract. Anti-stress and nootropic activity activities of aqueous extract of Artocarpus heterophyllus fruit extract were estimated as locomotor and working memory in rats in a Y-maze apparatus. The in vitro antioxidant activity was determined based on the ability of the Artocarpus heterophyllus to scavenge free radicals. Daily administration of aqueous extract of Artocarpus heterophyllus at doses of 100, 200 and 300 mg per kg body weight one hour prior to induction of stress increased the stress-induced urinary biomarker levels in a dose-dependent manner. Artocarpus heterophyllus treatment showed significant dose-dependent variation in noninvasive biomarker levels in urine samples of rats taken after 24 h. Cognition, determined by working memory and locomotor activity results, were shown to be dose-dependent. The results of this study suggest anti-stress and nootropic activity effect of Artocarpus heterophyllus in rodents.
- Publication
International Journal of Pharmacy & Life Sciences, 2017, Vol 8, Issue 5, p45
- ISSN
0976-7126
- Publication type
Academic Journal