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- Title
FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLET OF NIMODIPINE.
- Authors
Pandya, Krupa R.; Patel, Vijay K.
- Abstract
Nimodipine is long acting calcium channel blocker used to treat chronic angina, vasospastic angina and hypertension. In present research work an attempt has been made to prepare fast dissolving tablets of nimodipine with increased rate of dissolution may leads to increase bioavailability. Formulation of inclusion complex of poorly soluble Nimodipine by β Cyclodextrin and Hydroxy propyl β Cyclodextrin by different ratio (1:1), (1:2), (1:3) using solvent evaporation method. The papared inclusion complex evaluated by phase solubility study and job's plot.optimized inclusion complex Nimodipine:Hydroxy propyl β Cyclodextrin (1:2) ratio give enhanced solubility. After optimization of inclusion complex the fast dissolving tablet of Nimodipine Hydroxy propyl β Cyclodextrin inclusion complex were prepared by direct compression method. Sodium starch glycolate, croscarmellose sodium, crospovidone and kyron T 314 are used as a superdisintegrants. Drug polymer interactions were investigated using differential scanning calorimetry and Fourier transform infrared spectroscopy. The prepared formulation were evaluated for various parameters like weight variation, hardness, friability, drug content, disintegration time, wetting time, in vitro drug release.D15 was optimized formulation containing 5% Kyron T 314 showed less disintegration time 15 sec and wetting 10 sec and more than 99.12% drug release at 30 min. stability studies were carried out at 40 ± 2°C /75 ± 5% RH for formulation D15 for 1 month. Stability studies on the best formulation indicated that there was no significant change found in hardness, disintrgration time, wetting time and drug release of tablets.
- Publication
Pharma Science Monitor, 2015, Vol 6, Issue 2, p174
- ISSN
0976-9242
- Publication type
Academic Journal