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- Title
DEVELOPMENT AND VALIDATION OF DUAL WAVELENGTH UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TENELIGLIPTIN HYDROBROMIDE HYDRATE AND METFORMIN HYDROCHLORIDE IN COMBINED DOSAGE FORM.
- Authors
Shivlal, Surati Jasmina; B., Patel Vandana
- Abstract
A simple, accurate, precise, reproducible and economical Dual Wavelength UV Spectrophotometric Method for estimation of Teneligliptin Hydro bromide hydrate and Metformin Hydrochloride in tablet dosage form has been developed. Dual wavelength method is based on selection of wavelengths, where one drug shows equal absorbance (or difference between absorbance is zero) and other drug shows some response. The wavelengths selected for determination of Teneligliptin were 236 nm and 230.5 nm. Whereas, wavelengths selected for determination of Metformin were 238 nm and 249 nm. Methanol was taken as solvent. Regression analysis of Beer's plots showed good correlation in concentration range of 5 - 25 µg/ml for Teneligliptin and 2-10 µg/ml for Metformin. Recovery studies for Teneligliptin and Metformin were performed and the percentage recovery for both the drugs was obtained in the range of 98.54-101.55% confirming the accuracy of the proposed method. The precision (interday, intraday and repeatability) of method was found within limits. The proposed method was successfully applied to determination of these drugs in commercial tablets.
- Publication
Pharma Science Monitor, 2018, Vol 9, Issue 2, p301
- ISSN
0976-9242
- Publication type
Academic Journal