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- Title
COMPARATIVE STUDY OF ASPARAGUS GONOCLADOS BAKER AND STREBLUS ASPER LOUR FOR HEPATOPROTECTIVE ACTIVITY USING CARBON TETRACHLORIDE-INDUCED TOXICITY IN RATS.
- Authors
D., Tijare Ranajit; Beknal A.; Mahoorkar N.; Chandy, Vineeth
- Abstract
Medicinal plants are the wide source of the drugs for the treatment of acute and chronic diseases. These plants are the members of various families such as Legumonosae, Apocynaceae, Acanthaceae, Rubiaceae, Scrophulariaceae etc. Among these one plant Asparagus gonoclados Baker is commonly called as Shatavari belongs to the family Liliaceae which is the one of the species of Asparagus racemosus Wild. The root tubers of the plant were collected from the forest area of Western Ghats of Karnataka particularly located near to Madikere and Sakleshpoor district of Karnataka, and further authenticated in RRI, Karnataka. The ethano-botanical information indicates that the A. gonoclados is an effective source for the treatment of the various disorders such as liver disorder, renal impairment and whooping cough etc. The phytochemical examination showed the presence of phenolic compounds, flavonoids, saponins etc. which may be used for hepatoprotective activity, hence the present study was an attempt to prove the same. Similarly another plant, Streblus asper Lour was selected for the studies. During the studies plant showed the presence of flavonoid & phenolic content which ultimately showed the synergistic effect with A. gonoclados, hence the present study was carried out with same objective in 50:50 ratio. Studies proved that combination therapy showed the significant hepatoprotective activity as compared to single drug therapy, in carbon tetrachloride induced liver toxicity. Drug was safe up to 4500 mg/kg body weight. Study showed the significant reduction in SGPT, SGOT and bilirubin levels in animals treated with combine dose than the single dose treated animals when in term compared with the negative control animals, with P <0.001. Cholesterol and acyl carrier protein (ACP) levels also reduces in the combined drug treated animals more than the single dose treated animals with P value <0.001. Histopathological investigation showed the normalization of the hepatic cells in comparison to the negative and positive control animals.
- Publication
Pharma Science Monitor, 2018, Vol 9, Issue 2, p408
- ISSN
0976-9242
- Publication type
Academic Journal