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- Title
COMPARATIVE HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF TRIPHALA AND SOLID LIPID NANOPARTICLE IN ISONIAZID-RIFAMPIN AND TETRACYCLINE INDUCED HEPATOTOXICITY IN RATS.
- Authors
Tiwari, Swati; Jain, Neetesh Kumar
- Abstract
The aim of the present study was to investigate the effect of hepatoprotective activity of aqueous extract of triphala and solid lipid nanoparticle in isoniazid-rifampin and tetracycline induced hepatotoxicity in rats/mices. Wistar Albino rats and mice of either sex weighing between (200-250 and 35-40 gm) were divided in seven groups of each containing six rats/mices and treated for 21 days. Group I and II served as normal and toxic control, Group III were treated with Silymarin (25 mg/kg), and Group IV to VII were treated with aq. extract of triphala (100mg/kg), solid lipid nanoparticles of triphala (50mg/kg), gallic acid (50mg/kg) and solid lipid nanoparticles of gallic acid respectively. The biochemical markers like (AST, ALT, ALP and serum bilirubin) were estimated. The in vivo antioxidant activity was determined by estimating the tissue levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (LPO) and histopathology of liver was also carried out. The triphala/bioactive & their formulation (100 and 50mg/kg) produced significant effect by decreasing the activity or level of AST, ALT, ALP and serum bilirubin and while it significantly increased the levels of tissue GSH, SOD and CAT in a dose-dependent manner. From the present study it can be concluded that aqueous extract of triphala/bioactive & their formulation possesses hepatoprotective activity against isoniazid-rifampin and tetracycline induced hepatotoxicity.
- Publication
Journal of Advanced Scientific Research, 2020, Vol 11, p48
- ISSN
0976-9595
- Publication type
Academic Journal