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- Title
Expression and clinical significance of serine-threonine kinase/mammalian target of rapamycin/p70 S6K signal pathway in oral squamous cell carcinoma.
- Authors
Jia Jieru; Liang Shuang; Liu Jiyuan; Zhao Jun; Tang Xiufa
- Abstract
Objective To investigate the expressions of serine-threonine kinase (Akt)/ mammalian target of rapamycin (mTOR)/p?0 S6K in oral squamous cell carcinoma (OSCC) and provide references for early diagnosis and prognosis evaluation of OSCC. Methods A total of 51 cases of OSCC, 10 cases of paracancerous mucosa, and 10 cases of normal oral mucosa were collected. The expressions of Akt/mTOR/p70 S6K in these cases were detected using the SP method of immunohistochemistry. The correlation between their expressions in OSCC was also analyzed. Results The positive expressions of p-Akt, p-mTOR, and p70 S6K in OSCC were significantly higher than those in normal oral mucosa and paracancerous mucosa. The expressions of p-Akt, p-mTOR, and p70 S6K in OSCC were not correlated with age, gender, and clinical stage; by comparison, these expressions were correlated with lymph node metastasis and pathological grade. Strong positive correlations were also observed between the expressions of p-Akt, p-mTOR, and p70 S6K in OSCC. Conclusion Akt/mTOR/p70 S6K signaling molecules exhibit active expressions in OSCC and may be implicated in the occurrence and development of OSCC.
- Publication
West China Journal of Stomatology, 2014, Vol 32, Issue 5, p504
- ISSN
1000-1182
- Publication type
Academic Journal
- DOI
10.7518/hxkq.2014.05.018