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- Title
Clinical Research of Crizotinib in Advanced Non-small Cell Lung Cancer.
- Authors
Haibo ZHU; Xiaoyu XU; Ling WANG
- Abstract
At present, in the treatment of non-small cell lung cancer (NSCLC), targeted therapy has an important status. After epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs), crizotinib targeted at EML4-ALK fusion gene becomes a significant drug of molecular targeted therapy in NSCLC. Phase I and II clinical trials prove that crizotinib is effective for treatment of activating EML4-ALK mutation in advanced NSCLC patients, little side-effect, and well tolerated. Recently, crizotinib can inhibit ROS1 receptor tyrosine kinase and show extraordinary significant antitumor activity in ROS1-rearranged NSCLC. Drug resistance also exists in crizotinib. The mechanism of drug resistance needs further research. In this study, a review is performed in the mechanism and pharmacokinetics of crizotinib, and the clinical progress of treatment in advanced NSCLC.
- Publication
Chinese Journal of Lung Cancer, 2013, Vol 16, Issue 6, p321
- ISSN
1009-3419
- Publication type
Academic Journal
- DOI
10.3779/j.issn.1009-3419.2013.06.09