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- Title
Neuroprotective properties of Madecassoside from Centella asiatica after hypoxic-ischemic injury.
- Authors
Shu Qing Li; Yong Sheng Xie; Qing Wen Meng; Jing Zhang; Tao Zhang
- Abstract
Madecassoside is one of increasingly used constituent of Centella asiatica, a frequently prescribed crude drug in South eastern Asia and China for wound healing. In the present experiment, it exposes the neuroprotective nature of Madecassoside in GT1-7 cell lines, further, which the antioxidant activities are performed. The cellular toxicity was assessed using 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay with increased cell viability with IC50 2.5μg/ml. the regulation of antioxidant levels showed changes in madecassoside treated cell lysate viz., SOD assay. Also, the antioxidative assays confirmed the negligible cellular damage caused to the GT1-7 cell lines. Hence, the results advocate that the current antioxidant and antitumor activity be justified by the high concentration of phenolic constituents, primarily the triterpene present in the C. asiatica.
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2016, Vol 29, Issue 6, p2047
- ISSN
1011-601X
- Publication type
Academic Journal