We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis of some new N-(alkyl/aralkyl)-N-(4-methoxyphenethyl) benzenesulfonamides as antibacterial agents against Escherichia coli.
- Authors
Abbasi, Muhammad Athar; Fatima, Zareen; Aziz-ur-Rehman; Siddiqui, Sabahat Zahra; Shah, Syed Adnan Ali; Shahid, Muhammad; Fatima, Hina
- Abstract
The present study comprises the synthesis of a new series of benzenesulfonamides derived from N-sulfonation of 2-(4-methoxyphenyl)-1-ethanamine (1). The synthesis was initiated by the reaction of 2-(4-methoxyphenyl)-1-ethanamine (1) with benzenesulfonyl chloride (2), to yield N-(4-methoxyphenethyl)benzenesulfonamide (3). This parent molecule 3 was subsequently treated with various alkyl/aralkyl halides (4a-j) in N,N-dimethylformamide (DMF) and in the presence of a weak base lithium hydride (LiH) to obtain various N-(alkyl/aralkyl)-N-(4-methoxyphenethyl) benzenesulfonamides (5a-j). The characterization of these derivatives was carried out by spectroscopic techniques like IR, ¹H-NMR, and 13C-NMR. Elemental analysis also supported this data. The biofilm inhibitory action of all the synthesized compounds was carried out on Escherichia coli and some of the compounds were identified to be very suitable inhibitors of this bacterial strain. Furthermore, the molecules were also tested for their cytotoxicity behavior to assess their utility as less cytotoxic therapeutic agents.
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2019, Vol 32, Issue 5, p1957
- ISSN
1011-601X
- Publication type
Academic Journal