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- Title
Differential Regulation of Ciliary Neurotrophic Factor and Its Receptor in the Rat Hippocampus in Response to Kainic Acid-induced Excitotoxicity.
- Authors
Jeong-Sun Choi; Seong Yun Kim; Hyun-Jung Park; Jung-Ho Cha; Yun-Sik Choi; Jin-Woong Chung; Myung-Hoon Chun; Mun-Yong Lee
- Abstract
We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRα), in the hippocampus following intraperitoneal administration of a convul-sant dose of kainic acid (KA). Immunohistochemistry and immunoblotting showed that CNTF levels rose dramatically between day 1 and day 10, and that the CNTF was located in reactive astrocytes. In contrast, upregulation of CNTFRα mRNA, occurred in neurons as well as astrocytes. A rapid, and short-lived (3 h-2 d) increase in CNTFRα was also observed in the more resistant granule cells and CA2 pyramidal neurons. The increase in astrocytes was detected by day 1 and was sustained for more than 5 d. These results show that CNTF and CNTFRα are differentially regulated in hippocampal neurons and reactive astrocytes following KA injection, indicating that these proteins may be involved in the regulation of astrocyte and neuronal degenerative responses.
- Publication
Molecules & Cells (Springer Science & Business Media B.V.), 2004, Vol 17, Issue 2, p292
- ISSN
1016-8478
- Publication type
Academic Journal
- DOI
10.1016/s1016-8478(23)13040-8