We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ISONIAZID (INH); HEPATOPROTECTIVE EFFECTS OF HONEY IN ISONIAZID (INH) INDUCED HEPATOTOXICITY IN RABBITS.
- Authors
Aleem, Umer; Shah, Rahman; Khan, Noor; Suliman, M.
- Abstract
Objectives: Hepatotoxicity is the most complicated side effect of isoniazid (inh) in the patient treated for tuberculosis. In causes 8-30% hepatotoxicity in the developing world. Metabolism of INH produces a metabolite, called acetyl isoniazid. In this study hepatoprotective effect of honey, in isoniazid induced animal model was assessed. Study Design: Randomized control trial. Setting: Saidu Medical College, Saidu Sharif Swat, KP. Period: October To December 2017. Material and Methods: 40 healthy male rabbits were assigned randomly to the group i, ii, iii and iv by using lottery method. Ten animals were grouped each row. The isoniazid-induced hepatotoxic model was created by giving 50 mg inh/kg orally on daily basis for eleven days. Group i was taken as negative control group ii as a positive control. Group iii and iv were experimental groups treated with 50 mg/kg/day and 100 mg/kg/day buckwheat honey respectively for eleven days. SPSS Version 16 software was used, mean, s.d. were determined in all the groups. Values of serum bilirubin, sgpt, and alkaline phosphatase were compared with each other using pairt-test. Results: SGPT, Serum bilirubin, and alkaline phosphatase were obtained in all the animals. Comparing group 1 negative control with group 2, 3 and 4 shows statistical significance, (p=0.00). Comparing group 2 positive control with 3 and 4 shows statistical significance, (p=0.00). Further comparing group 3 with group 4 also shows statistical significance (p=0.00). Conclusion: From the above finding, it has been revealed that honey has got a protective effect in regressing hepatitis that has been induced in rabbit's model by high doses of isoniazid. Related studies performed in which different chemicals and drugs have been tried for their protective role in isoniazid induced hepatitis also shows a similar type of results.
- Publication
Professional Medical Journal, 2018, Vol 25, Issue 10, p1587
- ISSN
1024-8919
- Publication type
Academic Journal
- DOI
10.29309/TPMJ/18.4635