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- Title
Comparison of Oral Lichen Planus and Systemic Lupus Erythematosus in Interleukins Level.
- Authors
Agha-Hosseini, Farzaneh; Moosavi, Mahdieh-Sadat; Tabrizi, Mina Hajifaraj
- Abstract
Lichen planus (LP) is a chronic inflammatory mucocutaneous disorder with unknown etiology. Systemic lupus erythematosus (SLE) is known as a prototypic autoimmune disease. Cytokines play a key role in the pathogenesis of both diseases. Various cytokines, such as interleukin 6 (IL-6), interleukin 10 (IL-10), interferon alpha (INF-a), and Tumor Necrosis Factor-alpha (TNF-a) can serve as biomarkersto predict SLE severity and monitor disease activity. In this review, we compare interleukins in oral lichen planus and lupus erythematosus as an autoimmune disease prototype. So, this review may provide insight for researchers in completing the cytokine network in OLP. Among the etiologic factors, the imbalance between Th-1 and Th-2 cytokine production plays an important role in the development of both diseases. By understanding cytokines and immunoregulatory networks of cytokines in these patients, appropriate treatment can be offered. There are many limitations in cytokine studies, which we have described in this article.
- Publication
Archives of Iranian Medicine (AIM), 2015, Vol 18, Issue 10, p703
- ISSN
1029-2977
- Publication type
Academic Journal
- DOI
0151810/AIM.0011