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- Title
Serotonin Norepinephrine Reuptake Inhibitors: Spectrum of Efficacy in Major Depressive Disorder.
- Authors
Papakostas, George I.
- Abstract
Randomized, double-blind, placebo-controlled trials remain the gold standard by which the efficacy of a particular pharmacologic intervention for the treatment of a medical disorder or condition is proven or ruled out. This is particularly true for major depressive disorder (MDD) and anxiety disorders, where the magnitude and variability (from one trial to another) of the placebo response remains considerable despite efforts to minimize its effects in antidepressant efficacy trials. This article will summarize evidence establishing the efficacy of four serotonin norepinephrine reuptake inhibitors--venlafaxine, desvenlafaxine succinate, duloxetine, and milnacipran--for the treatment of MDD.
- Publication
Primary Psychiatry, 2009, Vol 16, Issue 5, p16
- ISSN
1082-6319
- Publication type
Academic Journal