We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet.
- Authors
Nagy, Fayrouz M.; Taha, Nabil M.; Mandour, Abd El Wahab A.; Lebda, Mohamed A.; Hashem, Aml S.
- Abstract
Hyrperlipidemia refers to a metabolic disorder characterized by alterations in serum lipid and lipoprotein patterns as low density lipoprotein cholesterol ( LDL-c) , high density lipoprotein cholesterol (HDL-c )and very low density lipoprotein cholesterol( VLDL-c ) and is also identified as dyslipidemia which is associated with insulin resistance and type 2 diabetes mellitus (T2DMS). Berberine is a alkaloid plant with a long history of medicinal uses in both traditional and Chinese medicine . Our study was carried out on 40 male albino rats. Hyperlipidemia was induced by feeding rats high fat diet for 8 weeks after which insulin resistance was developed as aconsequance to hyperlipidemia . Berberine chloride was administered orally after induction of hyperlipidemia for 2 weeks by stomach tube. Our result showed that serum lipid profile (TAG , TC , LDL-c) increased while HDL-c level was decrease moreover blood glucose level , insulin level , fructosamine level ,HbA1c level and HOMA-IR level increased at end of 8 weeks after development of hyperlipidemia . Addition of berberine chloride showed protective effect as decreased serum triglycerides , total cholesterol and LDL-c levels and increased HDL-c level more over it reduced insulin , glucose , fructosamine ,HbA1c and HOMA-IR levels. In conclusion, administration of berberine chloride showed desirable and promising hypolipidemia and hypoglycemia activity.
- Publication
Alexandria Journal of Veterinary Sciences, 2016, Vol 51, Issue 2, p142
- ISSN
1110-2047
- Publication type
Academic Journal
- DOI
10.5455/ajvs.240399