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- Title
SYSTEMIC CHRONIC INFLAMMATION AND COLORECTAL CANCER - AN UNSOLVED PUZZLE.
- Authors
Mihăiţă, Pătrăşescu; Petruţ, Nuţă; Raluca, Costache; Săndica, Bucurică; Bogdan, Macadon; Andrada, Popescu; Vasile, Balaban; Florentina, Ioniţă Radu; Mariana, Jinga
- Abstract
The link between chronic inflammation and cancers has the support of a large pool of clinical and epidemiological studies. Chronic inflammation is involved in tumor development, tumor growth, progression and metastasis and, also, in resistance to therapy. As it is already acknowledged inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn disease are closely linked to an increased risk of colorectal cancer as high as 10 fold. Various inflammatory cytokines have been studied as they facilitate the tumor development. Among those the most relevant are: C reactive protein, interleukin 6 and tumor necrosis factor alpha. The majority of published studies points toward a positive link between the increased serum level of those inflammatory molecules and the risk of colorectal cancer. Future studies are needed to address the issue of novel oncological therapy that interfere with inflammatory mechanism of colorectal cancer.
- Publication
Internal Medicine / Medicină Internă, 2016, Vol 13, Issue 3, p51
- ISSN
1220-5818
- Publication type
Academic Journal