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- Title
GREEN CATALYTIC SYNTHESIS OF PHENPROCOUMON.
- Authors
CANDU, NATALIA; TOMPOS, ANDRAS; TALAS, EMILIA; TUDORACHE, MADALINA; COMAN, SIMONA M.
- Abstract
The catalytic potential of triflate-based activated carbon composites has been investigated in phenprocoumon (C3-alkylated compound) synthesis, through the alkylation of 4-hydroxycoumarin with phenyl-ethyl-carbinol. The main reaction products are O- and C3-alkylated compounds. However, O-alkylated product is more easily produced to the detriment of the C3-alkylated compound, the selective synthesis of the last being a challenge in these conditions. Both the conversion of 4-hydroxycoumarin and the selectivity to C3-alkylated compound is highly influenced by the physico-chemical characteristics of the catalysts and the reaction conditions. The highest 4-hydroxycoumarin conversions (16.0- 30.0%) and selectivity to phenprocoumon (94.0-99.7%) were achieved with triflate-based activated carbon composites, characterized by the existence of strong Brønsted acid sites, optimal Lewis/Brønsted acid ratio, and bimodal micro-/mesoporosity.
- Publication
Studia Universitatis Babes-Bolyai, Chemia, 2019, Vol 64, Issue 3, p47
- ISSN
1224-7154
- Publication type
Academic Journal
- DOI
10.24193/subbchem.2019.3.04