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- Title
OKSİDATİF STRES DURUMUNDA ANTİOKSİDAN ENZİMLERİN ROLÜ - SÜPEROKSİT DİSMUTAZ (SOD), KATALAZ (CAT) VE GLUTATYON PEROKSİDAZ (GPx).
- Authors
ASLANKOÇ, Rahime; DEMİRCİ, Deniz; İNAN, Ümmahan; YILDIZ, Mahmut; ÖZTÜRK, Ahmet; ÇETİN, Mevlüt; SAVRAN, E. Şirin; YILMAZ, Burak
- Abstract
The human body has a complex antioxidant defense system that is enzymatic and non-enzymatic. Antioxidant mechanisms develop a defense system against free radicals which have harmful effects on body tissues. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) occur the basic line of defense against free radicals in the cell. Especially free radicals are produced continuously through production of mitochondrial energy. The accumulation of free radicals in the cell causes oxidative stress and cellular damage. It is stated that increased reactive oxygen species in the cell, play a role in the pathogenesis of many diseases such as neurodegenerative, cardiovascular, diabetic and kidney diseases. The role of SOD, CAT, and GPx in preventing cellular damage is constantly being investigated. This review article was written to explain the role of SOD, CAT and GPx antioxidant enzymes in preventing oxidative stress.
- Publication
Medical Journal of Suleyman Demirel University, 2019, Vol 26, Issue 3, p362
- ISSN
1300-7416
- Publication type
Academic Journal
- DOI
10.17343/sdutfd.566969