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- Title
FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM OF RITONAVIR.
- Authors
BISWAS, Moumita; GUPTA, Roop Narayan; PARHI, Rabinarayan; SETHI, Kalyan Kumar; SAHOO, Suvendu Kumar
- Abstract
The purpose of the research work was to develop a floating drug delivery system of ritonavir (RN) in order to prolong the gastric residence time and increase its bioavailability. The floating tablets of RN were prepared by direct compression technique, using polymers such as different grades of hydroxvpropyl methylcellulose (HPMC, Metliocel E15LV. E50LV, K100LV and K4M) and polyvinyl pyrrolidone (PVP K30). Sodium bicarbonate was used as gas releasing agent. The formulations were optimized on the basis of matrix integrity, duration of floating, swelling behaviour and in vitro drug release. Except series FA, where floating time was 10 hr, other series such as FB, FC and FD were showing more than 12 hr of floating time. The highest average swelling index of 170.68 ± 0.45 was found in FD3 batch. The in vitro drug release indicated extended release of RN and more than 62 percent of drug was released at the end of the 12 hr for ad the batches. The mechanism of RN release from the floating tablets for FA, FB and FC series is anomalous diffusion transport and follows zero order kinetics, but FD series indicated Higuchi kinetics with release rate exponent (n) of 0.44. Further, the scanning electron microscopy showed porous structured formed on the tablet surface at different times (0, 3, 6, 9 and 12 hr) of dissolution for the selected batch FC3. Finally, FC3 batch showed no significant change in above parameters after storage at room temperature (28-32°C), 40°C and 50°C for one month.
- Publication
Turkish Journal of Pharmaceutical Sciences, 2013, Vol 10, Issue 1, p69
- ISSN
1304-530X
- Publication type
Academic Journal