We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Healing effect of Hericium erinaceus in experimental peripheral neuropathy model.
- Authors
Üstün, Ramazan; Aden, Mustafa; Oğuz, Elif Kaval; Taşpınar, Filiz; Şeker, Ayşe
- Abstract
Objective: Cisplatin is one of the most effective anticancer drugs used in the treatment of various solid tumors. However, cisplatin-induced peripheral neuropathy (CIPN) is the most common and dose-limiting side effect of cisplatin. In clinic, it is aimed to increase the survival rate and increase the quality of life of cancer patients receiving chemotherapy. Lion's mane (Hericium erinaceus) mushroom (HE) is an edible and medical fungus. It has been reported that HE exhibits anti-cancer and neuroprotective activities. The current study was aimed to explore the regenerative effect of HE on a peripheral neuropathy model in BALB/c mice. Methods: In the present study, the experimental CIPN model was created using cisplatin in BALB/c mice. For treatment of the CIPN, the hot aqueous extract of HE was prepared and applied to the animals intraperitoneally. Its therapeutic effects on peripheral nerves were investigated by body weight changes' analysis, electromyographic (EMG) measurements, and immunohistochemistry technics using confocal laser scanning microscopy. Results: HE treatment significantly prevented cisplatininduced weight loss (p<0.05). In EMG measurements, although there is no significant difference among the groups, HE treatment showed a trend in functional recovery by increasing compound muscle action potential (CMAP) amplitude and accelerating latency period. Immunohistochemical findings exhibited that HE treatment initiates regeneration of myelin and axon significantly in animals with CIPN (p<0.05). Conclusion: HE exhibited therapeutic effects on a mouse model of peripheral neuropathy. HE may be an efficient and safe therapeutic agent to be used in peripheral neuropathy. Therefore, our study warrants further detailed investigation of HE as a potential therapeutic agent.
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2019, Vol 13, Issue S1, pS37
- ISSN
1307-8798
- Publication type
Academic Journal