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- Title
The effect of agomelatin on pain threshold and neurogenesis in depressed male rats.
- Authors
Bakkaloğlu, Umut; Babur, Ercan; Tan, Burak; Yazgan, Kamile; Yalçın, Betül; Yay, Arzu Hanım; Gölgeli, Asuman
- Abstract
Objective: It is known that depression reduces the pain threshold and neurogenesis. New drugs for the treatment of depression and secondary effects of depression continue to be produced. Despite these drugs, depression is still an important health problem. The aim of this study was to show the effect of agomelatine on neurogenesis and pain threshold in depressive rats. Methods: 40 male Wistar albino rats (10-12 weeks old) were used in the study. Rats were divided into four groups as control (CONT), control-agomelatine (KONT-AGO), depression (DEP), depression-agomeletin (DEP-AGO) groups. Depression model was developed based on the method developed by Porsolt and saline applied to this group for 15 days. DEP-AGO group was administered agomelatin (1 mg/kg) with gavage for 15 days after the depression model was developed. CONT-AGO was applied agomelatin (1 mg/kg) for 15 days without ZST. Sucrose preference test was applied to all groups. The pain thresholds were measured with hot plate and tail flick methods of all groups. Sections from the hippocampus region of the brain were taken and neurogenesis was demonstrated by evaluating doublecortin (DCX) immunoreactivity intensity. Statistical comparisons between groups were evaluated by one-way ANOVA followed post-hoc LSD test. Results: When the sucrose preference, pain threshold (avoidance times) and DCX immunoreactivity were evaluated, it was found that DEP group rats decreased significantly compared that in CONT and CONT-AGO group (p<0.05). In addition, when the same parameters were evaluated, it was found that DEP-AGO group rats increased significantly compared to DEP group (p<0.05). No significant difference was found between the CONT, CONT-AGO and DEP-AGO groups (p>0.05). Conclusion: Study findings support that depression decreases pain threshold and neurogenesis and that melatonin analog agomelatine, which is used as antidepressant, normalizes these effects of depression.
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2019, Vol 13, Issue S1, pS51
- ISSN
1307-8798
- Publication type
Academic Journal