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- Title
ПРИЛОЖЕНИЕ НА НОВА ГЕНЕРАЦИЯ РЕТИНОИДИ В СЪВРЕМЕННАТА ТЕРАПИЯ НА ОНКОЛОГИЧНИ ЗАБОЛЯВАНИЯ
- Authors
Агова, Надя; Георгиева, Светлана; Колева, Яна; Георгиева, Мая; Златков, Александър
- Abstract
Retinoids comprise a family of polyisoprenoid lipids which include vitamin A (retinol) and its natural and synthetic analogs. Vitamin A (retinol) and its natural and synthetic derivatives (retinoids) are involved in several important physiological processes in human body. Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoids are effective therapy for some precancerous lesions, the treatment of acute promyelocytic leukemia (APL), T-cell lymphoma, and the prevention of malignancies in high-risk cancer groups. Breast cancer still remains a major problem in its incidence, morbidity and mortality. Retinoids, natural and synthetic derivatives of vitamin A, possess antiproliferative and proapoptotic properties, making them a promising class of chemopreventive agents against breast cancer. Studies have shown that new generation retinoids can inhibit the growth of normal and malignant breast cells.
- Publication
Management & Education / Upravlenie i Obrazovanie, 2017, Vol 13, p154
- ISSN
1312-6121
- Publication type
Academic Journal