We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
THE IMPROVEMENT OF INSULIN RESISTANCE AND THE ANTIOXIDANT CAPACITY IN TYPE 2 DIABETES MELLITUS RATS WITH WHITELEG SHRIMP SHELL POWDER (LITOPENAEUS VANNAMEI).
- Authors
Ahriyasna, Risya; Agustini, Tri Winarni; Djamiatun, Kis; Primal, Def
- Abstract
As estimated having an increased incidence of about 50% until 2040, the diabetic condition could be augmented primarily from astaxanthin contained in carotenoids. This research examines and compares the influence of WSSP and AST complement on Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) level and Total Antioxidant Capacity (TAC) induced high-fat diet streptozotocin (HFD-STZ) in T2DM rats. WSSP 0.89gr/200gr/d (X1) and 1.77gr/200gr/d (X2) groups; and AST supplement 0.09mg/200gr/d (X3) groups were compared with both of positive (K1) and negative (K2) groups. The treatments were administered orally for 21 days to 25 Wistar rats which each group consisted of 5 rats. HOMA-IR and TAC levels were measured by ELISA and ABTs method respectively. TAC levels significantly increased in treatment groups than K1 group (p = 0.008). The increase in the TAC level of the X2 group was greater than the X1 group (p = 0.017). HOMA IR levels were significantly lower in treatment groups than K1 group (p = 0.009). X2 group had a greater decrease in HOMA IR levels compared to X1 (p = 0.016). In consequence, the research findings show a utilitarian effect of WSSP in increasing TAC and decreasing the HOMA-IR index.
- Publication
Slovak Journal of Food Sciences, 2021, Vol 15, p703
- ISSN
1338-9971
- Publication type
Academic Journal
- DOI
10.5219/1684