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- Title
Effects of Ischemia and Immobility on Muscle Atrophy in Rats.
- Authors
UMEI, NAMIKO; ONO, TAKEYA; HIRAYABU, HIDEAKI; OKI, SADAAKI; OTSUKA, AKIRA; OTAO, HIROSHI; MUTO, NORIO
- Abstract
[Purpose] The purpose of this study was to determine the effects of ischemia and immobility on muscle atrophy in rats. [Subjects] Twenty-one eight-week-old Wistar female rats were randomly divided into three experimental groups: "immobile", "ischemic and immobile", and "ischemic". The left hind limb of the "immobile" group was used as the "control" group. [Methods] Ischemia and/or immobility were applied to the right hind limbs of the experimental groups. The relative weight ratios of the soleus muscles and the soleus muscle fiber cross-section minor axes were used for the evaluation of muscle atrophy. [Results] The soleus muscle relative weight ratios were highest in the "normal" group and decreased in order in the following groups "ischemia", "ischemia and immobile", "immobile". The soleus muscle fiber cross-section minor axes were highest in the "normal" group and decreased in order in the following groups "ischemia", "immobile", "ischemia and immobile". [Conclusion] Our results suggest that muscle atrophy caused by immobility and that caused by ischemia are independent entities.
- Publication
Rigakuryoho Kagaku, 2011, Vol 26, Issue 2, p259
- ISSN
1341-1667
- Publication type
Academic Journal
- DOI
10.1589/rika.26.259