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- Title
Evaluation of Hepatoprotective Effects of Capparis spinosa in Induced Thallium Poisoning in Rats.
- Authors
Nashtar, Saad Badai
- Abstract
Introduction: Thallium is a highly toxic substance especially its salt compounds and thallium poisoning is a frequent medical condition in many world countries. Thallium causes wide spread systemic damage especially to the liver in this study. Objective: to evaluate the hepatoprotective effects of Capparis spinosa fruit extract on liver damage caused by induced thallium poisoned rat. Design: experimental randomized controlled trail. Materials and Methods: 36 white albino male and female rats were classified randomly into 3 groups 12 rats each. Group 1 normal (negative control) , group 2 thallium (positive control) in which rats were given 10 mg/kg thallium only, and group 3 (capparis group) in which the rats were given 200 mg/kg Capparis spinosa fruit extract for 5 successive days before administration of thallium dose 10 mg/kg. Results: Significant reduction of serum liver transaminases (AST and ALT) in Capparis spinosa treated group compared to highly elevated enzymes in thallium control group. Histopathological sections revealed reduced hepatocellular damage in comparison to thallium group. Discussion: these protective effects may be attributed to the antioxidant effects of Capparis spinosa fruit extract. Conclusion: Capparis spinosa fruit extract may have hepatoprotective effects against thallium liver injury.
- Publication
International Medical Journal, 2020, Vol 27, Issue 2, p172
- ISSN
1341-2051
- Publication type
Academic Journal