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Title
Transcriptional pharmacology of neurodegenerative disorders: novel venue towards neuroprotection against excitotoxicity?
Authors
Memo, M.; Segman, R.; Gritsenko, I.; Nemanov, L.; Lerer, B.; Kramer, I.; Zer-Zion, M.; Kletz, I.; Ebstein, R.P.
Abstract
Transcription factors NF-κB/Rel represent the point of convergence of several signalling pathways relevant to neurodegeneration. The finding that salicylates elicit neuroprotection via blockade of NF-κB provides new opportunities for pharmacological intervention.