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- Title
EFFECT OF STROBILANTHES CRISPUS LEAFY EXTRACTS IN LIPOLYSIS OF ADIPOSE TISSUE IN DIET INDUCED OBESE RATS.
- Authors
Z., Norhasnida; M., Suhaila; A. H., Azizah; R., Rozita; I., Maznah
- Abstract
Introduction: The objective of this study was to investigate the effects of Jin Batu (Strobilanthes crispus) leaf extract in assisting weight loss of diet-induced obese rats fed a normal rat chow diet in vivo. Methodology: Lean Sprague-Dawley rats (350-450g) were fed a high-fat diet containing 31.1% fat for 14 weeks to induce obesity. Obese rats were given S. crispus extract (1%w/w) in drinking water and standard rat chow diet for another 14 weeks. The assay for adipose tissue lipolysis effect was performed by measuring changes of adipose tissue weight, plasma leptin and glycerol level and lipoprotein lipase mRNA expression before and after treatment with S. crispus extract. The time course of body weight, food intake, organ weight (left and right inguinal, retroperitoneal and mesenteric adipose tissue, liver, heart and kidney), plasma parameters (triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein and insulin), fasting blood glucose and fecal output of total fat were measured. Hepatic histological examinations were also performed. Results: After 14 weeks, rats treated with S. crispus extract were found to have lower mean body weight, mean body weight gain and feed efficiency than control group. They also have significantly (p<0.05) lower adipose tissue and liver weight, and leptin level compared to control group. Lower glucose level and hepatic steatosis combined with high lipolysis rate and LPL mRNA expressed in adipose tissue was also noted in treated group. Conclusion: These results demonstrated that adding 1% (w/w) S. crispus extract to a normal rat chow diet could ameliorate obesity and fatty liver in obese rats better than normal rat chow diet alone.
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, p115
- ISSN
1394-195X
- Publication type
Academic Journal