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- Title
Hepatoprotective Activity of Jatropha curcas Leaf Extract against Carbon Tetrachloride-Induced Hepatotoxicity.
- Authors
Imtiyaz, Shaikh; Patil, K. S.; Singh, Anoop; Kute, S. H.; Mahajan, S. M.
- Abstract
The hepatoprotective effect of leaf extract of Jatropha curcas L. was investigated against carbon tetrachloride (CCl4)-induced acute hepatotoxicity in rats. Wistar albino rats were treated with pet. ether, alcoholic and aqueous leaf extract (200mg/kg , p.o.) for seven days along with CCl4 on alternate days. Biochemical parameters such as serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TBL) were estimated. The extracts showed protective effect by lowering serum levels of various biochemical parameters in the selected model. These biochemical observations were supplemented with histopathological examination of liver sections.
- Publication
Journal of Tropical Medicinal Plants, 2010, Vol 11, Issue 1, p53
- ISSN
1511-8525
- Publication type
Academic Journal