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- Title
(QOL19) The Mediterranean Diet and Fatigue, Depression, and Emotional Well-being in Multiple Sclerosis: A Study in Patient-Reported Outcomes.
- Authors
Bolling, Jamie; Rusch, Carley T.; Kraus, Alison; Tester, Nicole; Herndon, Nicole; Carlson, Aaron; Vervloet Sollero, Carlos; Gyang, Tirisham V.
- Abstract
Background: Multiple sclerosis (MS) is a chronic demyelinating inflammatory disease of the central nervous system and a leading cause of disability among young adults. It presents with a variety of neurologic symptoms, which can significantly affect the quality of life of affected individuals. Although no specific diet exists for MS, dietary factors show potential for beneficial effects on inflammation, neuroprotection, and repair. Increased dietary quality has been associated with lower disability and symptom burden in MS. Various diets, including ketogenic, fasting, Mediterranean, and plant-based diets produced mixed results in studies. The Mediterranean diet (MD) is high in antioxidants, fiber, and monoand polyunsaturated fatty acids as it emphasizes higher intake of fish, olive oil, fruits, and vegetables. Previous studies have shown the MD may be beneficial in risk reduction for cardiovascular diseases, type 2 diabetes, obesity, cognitive impairment, and brain atrophy. Limited studies have researched the relationship between MS outcomes and MD adherence. Preliminary evidence suggests that a MD may be beneficial in the MS population as it may be associated with reduced fatigue, impact of MS symptoms, and disability. Early findings warrant further investigation on the impact of an MD on MS outcomes to provide more evidence on the relationship of this diet on fatigue, cognitive function, and emotional wellbeing in MS. Objectives: To examine the relationship between adherence to the MD and fatigue, cognitive function, and emotional well-being, as captured by validated patient-reported outcomes in MS. Methods: Subjects will be recruited, consented, and enrolled from the University of Florida MS clinic. Adherence to the MD will be determined by using the validated 14-Item Mediterranean Diet Assessment Tool. Neuro-QOL questionnaires will score cognitive function and emotional well-being, while the validated Modified Fatigue Impact Scale will score fatigue. Data analysis will determine the relationship between adherence to the MD and fatigue, cognitive function, and emotional well-being. Results: Data collection is ongoing. Conclusions: Diet is an important factor to consider in comprehensive MS care and may have significant impact on quality of life. We hypothesize that MD will be associated with improved fatigue, cognitive function, and emotional well-being scores, although further research will better characterize its impact.
- Publication
International Journal of MS Care, 2020, Vol 22, Issue S2, p68
- ISSN
1537-2073
- Publication type
Academic Journal