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- Title
INTRADUODENAL INJECTION OF HEAT-KILLED LACTOBACILLUS BREVIS SBC8803 MODULATES AUTONOMIC NEUROTRANSMISSION IN THE GUT: INVOLVEMENT OF VAGAL AFFERENTS AND SEROTONIN RECEPTORS.
- Authors
Yuko Horii; Yasukazu Nakakita; Yoshiyuki Fujisaki; Hirotaka Kaneda; Tatsuro Shigyo; Katsuya Nagai
- Abstract
Previously, we found that intraduodenal administration of heat-killed Lactobacillus brevis SBC8803 (SBC8803) elevates both the efferent gastric vagal nerve activity (efferent GVNA) and the afferent intestinal vagal nerve activity (afferent IVNA) in rats. In this study, the effects of vagotomy and serotonin (5-HT) receptor antagonists on the above changes due to SBC8803 were examined in rats to clarify the mechanism. It was found that the elevation of efferent GVNA induced by SBC8803 was eliminated by subdiaphragmatic vagotomy, and inhibited by intracerebroventricular but not intravenous administration of ketanserin (5-HT2 antagonist), Moreover, both the efferent GVNA and the afferent IVNA elevations were suppressed by intracerebroventricular administration of granisetron (5-HT3 antagonist). Combining this with our previous findings that granisetron can produce the same effects intravenously, these findings suggest the following: 1) the efferent GVNA enhancement requires afferent vagal nerves, central but not peripheral 5-HT2 receptors, and both central and peripheral 5-HT3 receptors, and 2) the afferent IVNA enhancement requires central and peripheral 5-HT3 receptors. Moreover, these results implicate the afferent IVNA in the mechanism of the SBC8803-induced increase in efferent GVNA.
- Publication
Current Topics in Nutraceutical Research, 2015, Vol 13, Issue 1, p47
- ISSN
1540-7535
- Publication type
Academic Journal