We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An Idiosyncratic Reaction to Clopidogrel.
- Authors
Kapila, Aaysha; Chhabra, Lovely; Locke, Allison Diane; Patel, Pranav; Khanna, Atul; Reddy, Chakradhar M.; Young, Mark F.
- Abstract
Clopidogrel is an irreversible antiplatelet agent belonging to the thienopyridine group that acts to antagonize the adenosinediphosphate P2Y12 receptoron platelets. It thus inhibits the activation of platelet glycoprotein GPIIb/IIIa complex, which is essential for fibrinogen--platelet complex formation. Clopidogrel has widely replaced ticlopidine because of a much better clinical safety profile. Clopidogrel isa prodrug that requires hepatic activation to exert its antiplatelet effect. Hepatotoxicity with use of clopidogrel is a rare but clinically significant phenomenon. We report a case of clopidogrel-induced hepatotoxicity in an elderly white woman.
- Publication
Permanente Journal, 2015, Vol 19, Issue 1, p74
- ISSN
1552-5767
- Publication type
Academic Journal
- DOI
10.7812/TPP/14-040