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- Title
IMPROVING THE FUNCTIONAL DIVERSITY OF A LIBRARY OF LIVE AND INACTIVATED PROBIOTIC MICROORGANISMS.
- Authors
Sañudo, A. I.; Sempere, L.; Rodríguez-Nogales, A.; Duarte, J.; Olivares, M.; Bañuelos, O.
- Abstract
[he generation of large microorganism libraries has become an important goal in the investigation and discovery of new beneficial microorganisms; however, it is laborious and costly. Here, we describe a method to increase the sample number of microbiological libraries through physicochemical processes that modify the native properties of bacterial strains. A library of 336 microbiological samples was obtained from 2 8 probiotic strains, through seven inactivation procedures and three cell extraction methods. The library was validated by the analysis of the samples in three different in vitro assays: pancreatic lipase inhibition, pro-inflammatory cytokine reduction and angiotensin-converting enzyme inhibition. Twelve samples fi-om nine different bacterial strains showed biological activity in some of the screening assays.
- Publication
International Journal of Probiotics & Prebiotics, 2016, Vol 11, Issue 2, p67
- ISSN
1555-1431
- Publication type
Academic Journal