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- Title
Advanced Glycation End Products (AGEs) in Diabetic Patients with Systemic Lupus Erythematosus.
- Authors
Hussain, Fatma; Sheikh, Munir Ahmed; Maan, Mohammad Arif; Jamil, Amer
- Abstract
Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease has an increased risk for diabetes mellitus (DM) due to accelerated atherosclerosis. The accumulation of advanced glycation end products (AGEs) is recognized as one of the factors contributing to the progression of atherosclerosis. The purpose of this study was to evaluate the levels of AGEs in diabetic patients with SLE. This case-control study included one-hundred and sixteen people with diabetes mellitus (type 1 DM = 19, type 2 DM = 97) divided into two groups namely; diabetic patients with SLE (DSLE group; n = 07) and diabetic patients without SLE (D group; n = 109). Results showed that differences in plasma glucose, HbA1c, total proteins, non-enzymatic protein glycation and AGEs measurements in diabetic subjects with SLE and those without SLE were not significant (p > 0.05). All the patients were thoroughly examined to explore DM and SLE involvements. Arthritis, photosensitivity and nephropathy, retinopathy were most common SLE and DM associated clinical features. Diabetic patients with SLE can experience increased AGEs. The disastrous combination of DM and SLE doubles patient's risk of evolving several complications. Vigilance considerations by ophthalmologists, nephrologists and endocrinologists can reduce patient's uncertainty, allowing them to focus on health and better prospects.
- Publication
International Journal of Agriculture & Biology, 2012, Vol 14, Issue 3, p440
- ISSN
1560-8530
- Publication type
Academic Journal