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- Title
OXIDATIVE STRESS AND ANTIOXIDANTS IN BRAIN TUMORS.
- Authors
Papacocea, T.; Papacocea, R.; Bădărau, A.; Ion, A. D.; Buraga, I.; Gaman, L.; Papacocea, A.
- Abstract
The brain has a particular predisposition to oxidative stress which makes it vulnerable to free radicals. They trigger lipid peroxidation of the cellular membranes, oxidation of proteins and DNA leading to changes in chromosome structure, genetic mutation, and/or modulation of cell growth. It was shown that oxygen-derived free radicals play an important role in brain tumor development due to DNA strand braking, appearance of point mutations and aberrant DNA cross-linking. Consequently, a genomic instability is created which contributes to carcinogenesis. In the next steps of carcinogenesis, oxygen free radicals may initiate signal transduction pathways and activate fundamental transcription factors such as NF-κB, Nrf2 or HIF-1. In this context, the contribution of oxidative stress in brain tumors genesis and the role of antioxidants were analysed.
- Publication
Therapeutics, Pharmacology & Clinical Toxicology, 2011, Vol 15, Issue 3, p234
- ISSN
1583-0012
- Publication type
Academic Journal