We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DANTROLENE - A POSSIBLE ANTIOXIDANT EFFECT IN BLEOMYCIN INDUCED LUNG INJURY IN RATS.
- Authors
Tudor, R. C.; Stan, C. I.; Folescu, Roxana; Stan, Cătălina Daniela; Zamfir, Carmen Lacramioara
- Abstract
It is widely accepted the role of dantrolene as a calcium blocker with direct action on skeletal muscle, used to treat spaticity and involved in therapeutic management of malignant hyperthermia. More and more opinions sustain a possible antioxidant effect of dantrolene. Our study explored the possible protective effect of dantrolene in lung, after bleomycin exposure; bleomycin is a chemotherapeutic agent which determine pulmonary fibroses. Materials and methods: 21 male adult Wistar rats were randomly divided in 3 groups: control group(saline solution), BLM group (a single dose of 5mg/kg intratracheally administered bleomycin) and BLMD group(a single dose of 5mg/kg intratracheally administered bleomycin followed by dantrolene, 5mg/kg for 4 weeks). At the end of the experiment, pulmonary samples were taken and specifically treated for microscopic exam. SOD, as biochimic antioxidant marker, was also determined. Results: pulmonary fibroses was attenuated after dantrolene administration and SOD levels revealed antioxidant activity.
- Publication
Romanian Journal of Functional & Clinical, Macro & Microscopical Anatomy & of Anthropology / Revista Româna de Anatomie Functionala si Clinica, Macro si Microscopica si de Antropologie, 2015, Vol 14, Issue 3, p398
- ISSN
1583-4026
- Publication type
Academic Journal