We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
تأثير دوازده هفته تمرين هوازي بر کنترل متابولیک در مردان دیابتی نوع-2 مبتلا به نوروپاتی محیطی
- Authors
سیاه کوهیان, معرفت; اصغرپورارشد, مسعود; بلبلی, لطفعلی; جعفری, افشار; حصاری, فرزام شیخزاده
- Abstract
Background: Apoptosis in skeletal muscle plays an important role in tissue dysfunction disease such as muscle atrophy. Current evidence suggests that exercise trainings may alter apoptosis-related signaling in skeletal muscle. Therefore, the present study was investigated the effect of 12 weeks of aerobic training on some indices of skeletal muscle apoptosis in rats. Methods: This study was conducted as a two-group experimental design on 20 randomly selected three month old male rats. Then divided them into two groups of training group (n=10) and control group (n=10). Rats in training group participated in 12 weeks of aerobic training program. 48 hours after the last training session, the soleus muscle of rats in both group were isolated and Bax, Bcl2 and caspase-3 genes expression evaluated by Real Time-PCR. Results: The results indicated that there is a significant difference in gene expression of Bcl-2 (P< 0.01) and Bax to Bcl-2 ratio (P< 0.05) between control and training group. Furthermore, there was no significant difference between the two groups in expression of Bax and caspase-3 (P> 0.05). Conclusion: The 12 weeks of aerobic training was effective in increasing skeletal muscle mitochondrial anti-apoptotic protein. However, considering the alterations of caspase-3 expression, more researches are needed to identify the effects of exercise training on skeletal muscle apoptosis.
- Publication
Medical Journal of Tabriz University of Medical Sciences & Health Services, 2018, Vol 39, Issue 6, p35
- ISSN
1608-5671
- Publication type
Academic Journal