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- Title
Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal cord injury.
- Authors
Ghorbani, Meysam; Shahabi, Parviz; Karimi, Pouran; Javan, Mohammad; Bani, Soheila; Hoseini, Saba; Soltani-Zangbar, Hamid; Sadeghzadeh-Oskouei, Behnaz
- Abstract
Introduction: Spinal cord injury (SCI) is a condition which can lead to permanent loss of neurons, glial and precursor cells. According to the positive influences of electrical stimulation in the neurogenesis, we hypothesized that sub-threshold electrical stimulation in the presence of exogenous astrocyte may trigger the differential regulation of wingless-type3 (Wnt-3) and eukaryotic initiation factor-2α (eIF2α) mediators in spinal cord injured rats. Results: The results show that expression of Wnt-3 and eIF2α proteins significantly enhanced after 14 days in the electrical stimulation+ SCI+astrocyte group in comparison with SCI and SCI+astrocyte groups. Also, the expression of GFAP cells was significantly increased after 14 days by electrical stimulation compared with other groups. Electrical stimulation had no effect on expression of doublecortin after 14 days. Conclusion: This survey demonstrates that sub-threshold electrical stimulation upregulates Wnt-3 and eIF2α mediators. Also, GFAP marker expression has been increased in animals subjected to electrical stimulation. But there are no evidences based on doublecortin expression as a neurogenesis biomarker.
- Publication
Physiology & Pharmacology, 2020, Vol 24, Issue 1, p34
- ISSN
1735-0581
- Publication type
Academic Journal
- DOI
10.32598/ppj.24.1.30