We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hepatoprotective Activity of Hovenia dulcis Thumb. on Paracetamol Induced Liver Toxicity in Mice.
- Authors
Nhung Bui
- Abstract
Background/Aims This study was conducted to evaluate the hepatoprotective effects of Hovenia dulcis Thumb. in the liver damage induced by paracetamol in mice experiment. To evaluate acute hepatoprotective activity of ethanol extract of H. dulcis Thumb. on paracetamol induced liver toxicity in mice. Methods Swiss albino mice weighing 25±2 g were divided into three groups of ten animals: group 1, oral distilled water of 0.2 mL/10 g; group 2, oral distilled water and take paracetamol 400 mg/kg; group 3, oral Silymarin at the dose of 140 mg/kg/day and take paracetamol 400 mg/kg; group 4, oral of ethanol extract of H. dulcis Thumb. at the dose of 10 g/kg/day and take paracetamol 400 mg/kg. Swiss albino mice were oral with a single dose of 400 mg/kg paracetamol to induce toxicity, while H. dulcis Thumb. administered in a dose of 10 g/kg/day. Animals were treated daily by oral route of administration of administration one a day in the morning for successive 8 days and observed once daily. On the 8th day after taking 2 hours of reagent, mice were given oral paracetamol dose of 400 mg/kg. Mice were sacrificed 48 hours after paracetamol oral to determine serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and liver histopathology. Results The 8 days pretreatment of H. dulcis Thumb. at the oral dose of 10 g/kg increases the detoxified function of liver and reduces the increasing level of AST, ALT, reduced the inflammation, hepatocellular necrosis which was induced by paracetamol. Conclusions The ethanol extract of H. dulcis Thumb. at the dose of 10 g/kg body weight per 24 hours showed hepatic protective effect on paracetamol induced liver toxicity in mice.
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p92
- ISSN
1976-2283
- Publication type
Academic Journal