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- Title
Health Benefits of Bioactive Phytochemical Avicularin and Their Potential Role as Hepatoprotective Agent: In Vivo and In-Silico Data Analysis.
- Authors
Patel, Dines H.; Patel, Kanika
- Abstract
Background/Aims Flavonoids, alkaloids and terpenoids are the major class of phytochemicals which are beneficial for the treatment of human disorders including different types of cancer. Flavonoids have been well known for their anti-viral, anti-bacterial, anti- inflammatory, cardioprotective, anti-diabetic, anti-cancer and anti-aging properties. Avicularin is a glycoside of quercetin i.e., quercetin-3-α-l-arabino furanoside, and it has been found in Lindera erythrocarpa, Lespedeza cuneata, Rhododendron schlipenbachii and Psidium guajava. Methods Various pharmacological activities of avicularin have been evaluated and presented in the various databases along with important analytical techniques. Present work describes the detailed data collection of avicularin for the development of medicine for the treatment of liver disorders. Various in vivo and in-silico data analysis have performed to know the therapeutic potential of avicularin in human being. Results Important pharmacological data's revealed that avicularin have inflammatory, hepatoprotective, antiallergic, antioxidant, and anti-tumor activities. Avicularin also protect cardiomyocytes and hepatocytes against oxidative stress induced apoptosis. Avicularin can induce cytotoxicity in cancer lines and tumor tissues and has positive influence on human hepatocellular carcinoma and inhibit intracellular lipids accumulation. Role of avicularin in rheumatoid arthritis was also established with their underlying molecular mechanisms. Conclusions Recent interest in avicularin has focused on pharmacological investigations which exhibit potent hepatoprotective activity. Present work deals the importance of pharmacological activity and analytical aspects of avicularin which summarized recent developments in the health promoting properties of avicularin.
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p214
- ISSN
1976-2283
- Publication type
Academic Journal