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- Title
Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives.
- Authors
Patel, Kandarp H.; Patel, Yogesh S.
- Abstract
Novel series of ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a] pyrimidine-6-carboxylate (4a-g) heterocyclic compounds have been synthesized in a one-pot reaction under solvent-free conditions from 4-(naphthalen-2-yl)thiazol-2-amine (1), various aromatic benzaldehyde (2a-g) and ethylacetoacetate (3). All the synthesized compounds were duly characterized by physic chemical analysis and various spectrometric technique viz., NMR, CMR and FT-IR spectral features. Compounds 4a-g were screened for their in vitro antibacterial activity against Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacterial strains (Salmonella typhimurium and Escherichia coli). Compounds 4a-g were also examined for antifungal activity against different fungal strains, i.e. Penicillium expansum, Botryodiplodia theobromae, Nigrospora sp., and Trichothesium sp.
- Publication
Orbital: The Electronic Journal of Chemistry, 2017, Vol 9, Issue 4, p219
- ISSN
1984-6428
- Publication type
Academic Journal
- DOI
10.17807/orbital.v9i4.879