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- Title
Estimation of Grape Seed Oil Alleviative Role on Cadmium Toxicity in Male Mice.
- Authors
Elhamalawy, Osama H.; El makawy, Aida I.
- Abstract
Cadmium (Cd) is a non-degradable environmental pollutant, and has the ability to collect in the body organs causing humans and animals health risks. The present study was conducted to estimate the protective role of grape seed oil (GSO) against cadmium chloride (CdCl2) induced toxicity in male mice. Phenolics content and antioxidant capacity of GSO were measured. Male mice had gavages of CdCl2 at a dose of (7.48 mg/kg body weight (b. w.) once a day for 30 successive days, whereas they were orally administered GSO at 1 mL/kg b. w. once a day for 30 successive days either pre or plus CdCl2. After the treatment, liver enzymes, sperm characteristics and organs weights were investigated. Genotoxicity was evaluated using comet assay and micronucleus test. Results revealed that CdCl2 induced elevation in ALT and AST, significantly increased the relative weights of liver, decreased the testes weight, sperm count and declined motility and elevated DNA damage in tested cells compared to control group. In contrast, administration of GSO at two regimens restored the organs' weights to the normal range, ameliorated liver enzymes, improved the sperm physical characteristics and alleviated DNA damage compared to CdCl2 treated mice. Furthermore, GSO pre-administration was the best regimen in the attenuation of the toxic effects of CdCl2. It can be concluded that GSO may possess a protective role against the toxicity of CdCl2 male mice.
- Publication
Jordan Journal of Biological Sciences, 2020, Vol 13, Issue 1, p77
- ISSN
1995-6673
- Publication type
Academic Journal