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- Title
Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line.
- Authors
CREŢU, FLAVIA MARIA; STĂNOIU, B. P.; PISOSCHI, CĂTĂLINA GABRIELA; PREDESCU, ANCA MIHAELA; RĂU, GABRIELA
- Abstract
Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® Luminescent Cell Viability Assay. Both compounds tested proved a growth inhibition effect on this cell line in a dose-dependent manner. Our results showed that the compound with procaine effectively reduces breast cancer MDA-MB-231 cells viability and proliferation at higher concentration while that with salicylic acid had an inhibitory effect at lower concentrations and might be tested as an anticancer agent.
- Publication
Current Health Sciences Journal, 2017, Vol 43, Issue 4, p335
- ISSN
2067-0656
- Publication type
Academic Journal
- DOI
10.12865/CHSJ.43.04.08