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- Title
DRUG TREATMENT OF TOBACCO ADDICTION.
- Authors
Mărginean, Corina
- Abstract
Objective: Smoking, a chronic recurrent disease requires complex therapeutic interventions, drug therapy being the first intention. The aim of this presentation is to present the drug therapy and its efficacy in the treatment of cigarette smoking. Results: The treatment of tobacco addiction is made up of two components: pharmacotherapy and cognitive-behavioral therapy. Pharmacotherapy includes first-line drugs and reserve medication. First-line medication has proven effective, with a high level of safety being the first option in treating nicotine addiction. Reserve medication has a lower efficacy, more serious side effects and is recommended when first-line medication can not be used. First line medication is nicotine replacement therapy, bupropion (Zyban), varenicline (Champix). Nicotine replacement therapy (TSN) with different forms of presentation: Chewing gum, sublingual tablets, is used in smokers with low and moderate smoking, or for those with high tobacco dependence but with contraindications to other drugs. Effective combination like combined nicotine patches and chewing gum showed a 34% abstinence rate versus 24% for monotherapy for 12 weeks. Bupropion (Zyban), the first drug in the non-nicotinic treatment series, reduces the desire for smoking and attenuating weight gain secondary to smoking cessation. The rate of abstinence is 28% at 6 months after treatment and the combination with nicotine patches achieved a 12 month abstinence rate of 35.5% vs. 30.3%. Only for bupropion and 16.4% for nicotine patches. Varenicline (Champix) has increased efficacy, with 71% of patients receiving treatment for 24 weeks remaining abstinent and at 52 weeks follow-up. 44% were abstinent. In patients with COPD, the continued abstinence rate at week 9-12 was 42.3%. Conclusions: Drug treatment of tobacco use, in particular combined drug therapy, leads to higher rates of abstinence, leading to a decrease in the tobacco pandemic.
- Publication
Acta Medica Marisiensis, 2017, Vol 63, p8
- ISSN
2068-3324
- Publication type
Academic Journal