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- Title
The Effects of Nasal Continuous Positive Airway Pressure (nCPAP) Treatment on Fasting Serum Leptin Concentration in Patients with OSAHS.
- Authors
FAN Min-juan; HAI Bing; ZHANG Tao; ZHAO Guo-hou
- Abstract
Objective To evaluate the effects of nasal continuous positive airway pressure (nCPAP) treatment on fasting serum leptin concentration and insulin resistance in patients with OSAHS. Methods Fasting serum leptin levels, FPG, FINS, HOMA-IR, BMI, AHI, ESS, the lowest oxygen saturation, the mean oxygen saturation (Spo2) and the sleep time of oxygen saturation below 90% were measured before and after on nCPAP in 16 moderate- severe OSAHS patients. The correlations of the change of serum leptin levels, the change of insulin resistance and indicators of the change of OSAHS with treatment were analyzed. Results The serum leptin levels, AHI, the sleep time of oxygen saturation below 90%, ESS were significantly decreased after nCPAP treatment (P < 0.01), the nocturnal lowest SpO2 and the nocturnal average SpO2 were significantly increased after nCPAP treatment (P < 0.01), while HOMA-IR, FBG, FINS and BMI did not change after treatment. The change of serum leptin levels was positively correlated with the change of the nocturnal lowest SpO2 and the change of AHI in OSAHS patients with treatment. Conclusion nCPAP therapy can reduce the serum leptin levels, improve sleep-disordered breathing, but can not improve insulin resistance and fasting serum glucose, the change of serum leptin levels is correlated with the change of the nocturnal lowest SpO2 and the change of AHI in OSAHS patients with nCPAP treatment, indicating the importance of improving sleep-disorder in OSAHS patients.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 10, p131
- ISSN
2095-610X
- Publication type
Academic Journal