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- Title
Control of skeletal muscle growth: adaptive response during functional overload-induced hypertrophy and muscle regeneration in rodents.
- Authors
Chaillou, Thomas; Koulmann, Nathalie; Meunier, Adélie; Beaudry, Michèle; Bigard, et Xavier
- Abstract
The aim of this study was to compare the adaptation of the main intracellular pathways involved in the control of muscle mass in two specific rodent models of muscle growth: functional overloadinduced hypertrophy and muscle regeneration. We show that the activation of the protein synthesisrelated signaling Akt/mTOR is determinant in overload-induced hypertrophy, while it is associated with the inhibition of some proteolytic factors (MURF1, MAFbx and BNIP-3) during muscle regeneration. The inhibition of REDD1 in these two situations, and the one of BNIP-3 in injured muscles could contribute to optimize the process of protein synthesis. In contrast, the activation of the energetic sensor AMPK could be a direct consequence of the energy deficit induced by the increased protein synthesis.
- Publication
Movement & Sport Sciences / Science & Motricité, 2013, Issue 79, p43
- ISSN
2118-5735
- Publication type
Academic Journal
- DOI
10.1051/sm/2012028