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- Title
The investigation of the effect of propolis on nitrosative stress in the brain tissue of rats exposed to total head irradiation.
- Authors
TAYSI, Seyithan; ALAFANDİ, Nour; DEMİR, Elif; ÇINAR, Kadir; TARAKÇIOĞLU, Mehmet
- Abstract
The aim of this study is to investigate the radioprotective effects of propolis on the brain tissue of rats exposed to ionizing radiation, and its ability in reducing nitrosative stress resulting from ionizing radiation. Thirty six male Wistar-Albino rats were used in the study. The study groups consisted of 4 subgroups: 2 control groups, one irradiation only group (IR), and the last group is both IR exposed and propolis administered. All of the groups except the control groups received a single dose of 5 Gy on the first day of radiotherapy. Nitrosative stress parameters in the brain tissue were measured by spectrophotometry to determine whether protective effects of propolis were present. It was determined that NO, ONOO- values and NOS activity were significantly higher in the brain tissue of the rats in the radiotherapy only group in comparison to the both propolis and irradiation treated group. In conclusion, these findings suggest that the use of propolis has a protective effect against the adverse effects of nitrosative stress caused by ionizing radiation. However, to be assured of these beneficiary effects of propolis should be supported by further pharmacological and toxicological researches.
- Publication
Journal of Cellular Neuroscience & Oxidative Stress, 2018, Vol 10, Issue 2, p737
- ISSN
2149-7222
- Publication type
Academic Journal