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- Title
Raloxifene and tamoxifen reduces oxidative stress in brain of ovariectomized rats.
- Authors
Yazğan, Yener; Yazğan, Betül; Övey, İ. Suat; Nazıroğlu, Mustafa
- Abstract
It has been well known that estrogen has antioxidant role on cardiovascular, gastrointestinal and neurological systems. Estrogen deficiency may active the channels although supplementation of estrogen may inhibit the channels via its antioxidant properties and support antioxidant levels in the neurons. Raloxifene and tamoxifen are selective estrogen receptor modulators (SERMs). They exert tissue-selective agonist- antagonist effects on estrogen receptors. The antioxidant properties of raloxifene and tamoxifen may also have a regulator role in the brain of ovariectomized rats. We aimed to investigate the effects of estradiol, raloxifene and tamoxifen on the oxidative stress in brain of ovariectomized (OVX) rats. Forty female Wister Albino rats were divided into five groups: First group was used as control. Second group used as ovariectomized. Third, fourth and five groups received estrogen, tamoxifen and raloxifene, respectively. Estrogen, tamoxifen and raloxifene were subcutaneous given to these three groups for 14 days, after OVX. We determined an increase in lipid peroxidation (as MDA) levels in brain of ovariectomized rats. While raloxifene, tamoxifen and estrogen treatment reduce levels of MDA versus to ovariectomized group. In addition, effect of tamoxifen is clearer than estradiol and raloxifene. Although reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) levels were reduced by OVX they were increased by the three treatments. In conclusion, we observed those estrogen, tamoxifen and raloxifene administrations are beneficial on oxidative stress level in the brain of OVX rats by modulating antioxidant system.
- Publication
Journal of Cellular Neuroscience & Oxidative Stress, 2015, Vol 7, Issue 1, p426
- ISSN
2149-7222
- Publication type
Academic Journal